Comparative Pharmacology of Risperidone and Paliperidone
نویسندگان
چکیده
منابع مشابه
Comparative Pharmacology of Risperidone and Paliperidone
Antipsychotics, risperidone, and risperidone's active metabolite, paliperidone (9-hydroxyrisperidone), are related molecules used for the treatment of schizophrenia and related disorders. Differences in receptor binding, 5-HT2A/D2 (serotonin/dopamine) binding ratios, and mitochondrial proteomics suggest that the effects of risperidone and paliperidone on neuronal firing, regulation of mitochond...
متن کاملRisperidone Induced Amenorrhea Resolved by Paliperidone
*Corresponding author: Cedo D Miljevic, Institute of Mental Health, Palmoticeva 37, 11 000 Belgrade, Serbia, Tel: +381 62 252 317; Fax: +381 11 3239 153; E-mail: [email protected] Received Date: November 11, 2014, Accepted Date: December 15, 2014, Published Date: December 23, 2014 Copyright: © 2015 Cedo D Miljevic, et al., This is an open-access article distributed under the terms of the ...
متن کاملPaliperidone ER and oral risperidone in patients with schizophrenia: a comparative database analysis
BACKGROUND To compare the efficacy and tolerability of paliperidone extended-release (ER) with risperidone immediate-release using propensity score methodology. METHODS Six double-blind, randomized, placebo-controlled, short-term clinical trials for acute schizophrenia with availability of individual patient-level data were identified (3 per compound). Propensity score pairwise matching was u...
متن کاملDetermination of Plasma Concentration Reference Ranges for Risperidone and Paliperidone
Schizophrenia is a common disease managed by a range of interventions, with the primary treatment being antipsychotic medications (APS). Inadequate response, lack of adherence, and/or adverse events often prevent optimal therapeutic effects or therapeutic efficiency. Monitoring APS plasma concentrations can be used together with a full clinical evaluation to help improve patient care or offer b...
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ژورنال
عنوان ژورنال: Drugs in R&D
سال: 2015
ISSN: 1174-5886,1179-6901
DOI: 10.1007/s40268-015-0092-x